Adulphakdee, Abeedin
(2011)
MODELING OF HYALURONIC ACID CONTAINING CURCUMINLOADED
POLYLACTIC-CO-GLYCOLIC ACID BIOCONJUGATES FOR
TARGETED DELIVERY TO CANCER CELLS.
Universiti Teknologi PETRONAS.
(Unpublished)
Abstract
This project investigates the 3D molecular modeling of hyaluronic acid (HA),
curcumin, polylactic-co-glycolic acid (PLGA) and polyethylene glycol bis amine
(PEG-bis amine) and all the possible conjugated forms between the compounds as
bioconjugates for targeted delivery to cancer cells. Modeling work had been done
using Discovery Studios 2.5 from Accelrys Inc. USA. The study focuses on targeted
delivery of curcumin to colorectal cancer cells. The generated model will be used in
the studies of drug delivery to cancer cells.
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