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MOLECULAR MODELING OF HYALURONIC ACID CONTANING CISPLATIN-LOADED POLYLAGTIC-CO-GLYCOLIC ACID BIOCONJUGATES FOR TARGETED DELIVERY TO CANCER CELLS

Madthing, Abdulloh (2011) MOLECULAR MODELING OF HYALURONIC ACID CONTANING CISPLATIN-LOADED POLYLAGTIC-CO-GLYCOLIC ACID BIOCONJUGATES FOR TARGETED DELIVERY TO CANCER CELLS. Universiti Teknologi PETRONAS. (Unpublished)

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Abstract

This project will present the molecular modeling of hyaluronic acid (HA), cisplatin, polylactic-co-glycolic acid (PLGA) and PEG-his amine as uni-molecular modeling and also conjugated forms of multi-molecular modeling for targeted delivery to cancer cells in 3D format by using Discovery Studios 2.5 software from Accelrys Inc. USA. Colorectal cancer cell will be the case study for targeted drug delivery. The methodologies to be used include molecular modeling design are molecular modeling, model development of cisplatin, PLGA, and HA. The simulation studies on drug delivery to colorectal cancer cells of the bioconjugated forms of the compounds will also be carried on.

Item Type: Final Year Project
Academic Subject : Academic Department - Chemical Engineering - Ionic Liquid
Subject: T Technology > TP Chemical technology
Divisions: Engineering > Chemical
Depositing User: Users 2053 not found.
Date Deposited: 13 Nov 2013 15:45
Last Modified: 25 Jan 2017 09:41
URI: http://utpedia.utp.edu.my/id/eprint/10551

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