MOLECULAR MODELING OF HYALURONIC ACID CONTANING CISPLATIN-LOADED POLYLAGTIC-CO-GLYCOLIC ACID BIOCONJUGATES FOR TARGETED DELIVERY TO CANCER CELLS

This project will present the molecular modeling of hyaluronic acid (HA), cisplatin,
polylactic-co-glycolic acid (PLGA) and PEG-his amine as uni-molecular modeling
and also conjugated forms of multi-molecular modeling for targeted delivery to
cancer cells in 3D format by using Discovery Studios 2.5 software from Accelrys
Inc. USA. Colorectal cancer cell will be the case study for targeted drug delivery.
The methodologies to be used include molecular modeling design are molecular
modeling, model development of cisplatin, PLGA, and HA. The simulation studies
on drug delivery to colorectal cancer cells of the bioconjugated forms of the
compounds will also be carried on.