Welcome To UTPedia

We would like to introduce you, the new knowledge repository product called UTPedia. The UTP Electronic and Digital Intellectual Asset. It stores digitized version of thesis, final year project reports and past year examination questions.

Browse content of UTPedia using Year, Subject, Department and Author and Search for required document using Searching facilities included in UTPedia. UTPedia with full text are accessible for all registered users, whereas only the physical information and metadata can be retrieved by public users. UTPedia collaborating and connecting peoples with university’s intellectual works from anywhere.

Disclaimer - Universiti Teknologi PETRONAS shall not be liable for any loss or damage caused by the usage of any information obtained from this web site.Best viewed using Mozilla Firefox 3 or IE 7 with resolution 1024 x 768.

Effect of Co-solvent on the Solubility of a Sparingly Soluble Crystal

Humayun, Hudzaifah Yousof (2015) Effect of Co-solvent on the Solubility of a Sparingly Soluble Crystal. IRC, Universiti Teknologi PETRONAS. (Unpublished)

[img] PDF
Download (1MB)


Solubility data plays an important role in the industry. Measuring solubility of crystal in various solvent is a key factor in compound characterizing during the whole discovery and development process where it allows engineers to design and optimize crystallization process. Benzoic acid is a simple aromatic carboxylic acid, a colorless crystalline solid that is widely used in the pharmaceutical area, plasticizers, food preservative and niche in the lab use. This chemical shows low aqueous solubility and dissolution rate and this has become the main concern in the industry that require dissolution of this chemical. This research describe an approach to improve the solubility of benzoic acid by using co-solvent. The experiment was conducted in different percentage of co-solvent and at different temperature. Co-solvent solution is prepared by using glycerol in water by volume ratio. Benzoic acid is placed in the solvent and was let to stir for three hours. Three milliliter of solution was taken out and placed in a vile to let it dry at room temperature. Result shows the relation between solubility in different co-solvent and temperature whereby as the percentage of glycerol added increase, the solubility of benzoic acid increase. Same trend was depicted in term of solubility relation with temperature, as the temperature increase, amount of benzoic acid dissolve also increase. The analyses has shown that co-solvent is an effective method in increasing the dissolution rate of a sparingly soluble chemical and temperature plays important role in increasing the solubility. The main reason of conducting this study is because of the lack of literature data on the reaction between benzoic acid and glycerol.

Item Type: Final Year Project
Academic Subject : Academic Department - Chemical Engineering - Separation Process
Subject: T Technology > TP Chemical technology
Divisions: Engineering > Chemical
Depositing User: Users 5719 not found.
Date Deposited: 15 Apr 2016 10:31
Last Modified: 25 Jan 2017 09:34
URI: http://utpedia.utp.edu.my/id/eprint/16471

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...