KHAN, SAIMA
(2014)
EXTRATION OF PHENOLIC COMPOUND FROM NEPHELIUM LAPPACEUM
LEAVES FOR THE TREATMENT OF DIABETES.
Masters thesis, Universiti Teknologi PETRONAS.
Abstract
There has been an enormous attention in development of unconventional
medicines for the treatment of Type 2 diabetes, precisely selection for phytochemicals
with the capability to postponement or inhibit glucose absorption. Phenolic compound
from Nephelium lappaceum leaves was investigated using Gallic acid as a precursor.
The phenolic compound was extracted in 50, 70, 90 and 100% ethanol, methanol,
isopropanol and acetone with solid to solvent ratio (10:1 w/v ratio) at 45°C, 60°C and
75°C. The aim of present study was to provide in-vitro confirmation for potential
inhibition by FRAP assay, ABTS assay, a-amylase assay and a-glucosidase assay.
Characterization of Nephelium Lappaceum Green and Brown leaves was taken in
account. The percentage of moisture content was 33.14%o in semi-dried Brown leaves
and 51.24% in fresh Green leaves.
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