Modeling of Hyaluronan-Paclitaxel Targeted Delivery to Cancer Cells

This project investigates the 3-D molecular modeling of hyaluronan (HA), paclitaxel
as anticancer drug, glutaraldehyde as cross-linker and possible crosslinked form of
hyaluronic acid paclitaxel molecule along with various physical properties of unimolecule
and multi-molecules. Modeling work had been done using Discovery
Studios 2.5 from Accelrys Inc. USA. The study focuses on targeted delivery of
hyaluronan crosslink paclitaxel molecule nanoparticle to cancer cells in all-purpose.
The generated model will be used in the studies of drug delivery to cancer cells.