Welcome To UTPedia

We would like to introduce you, the new knowledge repository product called UTPedia. The UTP Electronic and Digital Intellectual Asset. It stores digitized version of thesis, final year project reports and past year examination questions.

Browse content of UTPedia using Year, Subject, Department and Author and Search for required document using Searching facilities included in UTPedia. UTPedia with full text are accessible for all registered users, whereas only the physical information and metadata can be retrieved by public users. UTPedia collaborating and connecting peoples with university’s intellectual works from anywhere.

Disclaimer - Universiti Teknologi PETRONAS shall not be liable for any loss or damage caused by the usage of any information obtained from this web site.Best viewed using Mozilla Firefox 3 or IE 7 with resolution 1024 x 768.

Modeling of hyaluronan-cisplatin targeted delivery in human colorectal cancer cells.

Adibah Bazilah binti Abdul Rani, Adibah Bazilah (2011) Modeling of hyaluronan-cisplatin targeted delivery in human colorectal cancer cells. UNIVERSITI TEKNOLOGI PETRONAS, Sri Iskandar,Tronoh,Perak. (Unpublished)

Download (1MB) | Preview


A modeling study on effective delivery of hyaluronan-cisplatin (HA-Pt) in human colorectal cancer was carried out. The main objective was to investigate how the HA-Pt conjugate improves drug delivery to colorectal cancer cells. The software, Discovery Studio 2.5 generates a three-dimensional simulation of the conjugated drug. The drug cisplatin is classified as an alkylating agent, the first platinum based anticancer drug that is effective against cancer. It inhibits DNA actual utilization by base pairing and causes a miscoding of DNA. Hyaluronan is a naturally occurring linear polymer that is a major component of extracellular matrix (ECM). The hyaluronan receptor, CD44 is overexpressed in cancer cells compared to normal cells. As a result, HA binding to CD44 can be explored for targeted anticancer drug delivery in human cancer cells.

Item Type: Final Year Project
Subject: T Technology > TP Chemical technology
Divisions: ?? sch_che ??
Depositing User: Users 5 not found.
Date Deposited: 25 Oct 2011 09:03
Last Modified: 25 Jan 2017 09:42
URI: http://utpedia.utp.edu.my/id/eprint/403

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...