Modeling of hyaluronan-cisplatin targeted delivery in human colorectal cancer cells.

A modeling study on effective delivery of hyaluronan-cisplatin (HA-Pt) in human colorectal cancer was carried out. The main objective was to investigate how the HA-Pt conjugate improves drug delivery to colorectal cancer cells. The software, Discovery Studio 2.5 generates a three-dimensional simulation of the conjugated drug. The drug cisplatin is classified as an alkylating agent, the first platinum based anticancer drug that is effective against cancer. It inhibits DNA actual utilization by base pairing and causes a miscoding of DNA. Hyaluronan is a naturally occurring linear polymer that is a major component of extracellular matrix (ECM). The hyaluronan receptor, CD44 is overexpressed in cancer cells compared to normal cells. As a result, HA binding to CD44 can be explored for targeted anticancer drug delivery in human cancer cells.