Welcome To UTPedia

We would like to introduce you, the new knowledge repository product called UTPedia. The UTP Electronic and Digital Intellectual Asset. It stores digitized version of thesis, dissertation, final year project reports and past year examination questions.

Browse content of UTPedia using Year, Subject, Department and Author and Search for required document using Searching facilities included in UTPedia. UTPedia with full text are accessible for all registered users, whereas only the physical information and metadata can be retrieved by public users. UTPedia collaborating and connecting peoples with university’s intellectual works from anywhere.

Disclaimer - Universiti Teknologi PETRONAS shall not be liable for any loss or damage caused by the usage of any information obtained from this web site.Best viewed using Mozilla Firefox 3 or IE 7 with resolution 1024 x 768.

Modeling of Hyaluronan-Curcumin Conjugate as Targeted Cancer Drug Delivery with Enhanced Water Solubility

Tnay , Xiang Qing (2011) Modeling of Hyaluronan-Curcumin Conjugate as Targeted Cancer Drug Delivery with Enhanced Water Solubility. Universiti Teknologi Petronas, Sri Iskandar,Tronoh,Perak. (Unpublished)

Full text not available from this repository.

Abstract

An anticancer drug has many new discoveries and breakthrough with the increasing understanding of our biological system and advancement in pharmacology. A big percentage of the newly discovered anticancer drugs face a problem of poor or little solubility. Furthermore, many potential anticancer drugs show cytotoxic behaviour toward normal cells besides killing deadly cancer cells. However natural anticancer compounds have been used to limit the systemic cytotoxicity and effectively deletion of deleterious cancer cells. Hyaluronic acid naturally found inside our body, highly viscous and versatile polymer open avenues toward drug or anticancer agent delivery. Due to Biocompatible and hydrophilic nature of Hyaluronic acid the problem of hydrophobic anticancer agent and drugs completely vanished. Hyaluronic acid is of the main ligand of CD44 cancer cells receptor. The ligand binding property makes hyaluronic acid as drug carrier for targeted delivery also. This project will explore curcumin, a yellow colour compound which has gained recognition as a drug effective towards killing cancer cells, yet not toxic to the human body. Modeling of Hyaluronan-Curcumin Conjugate as Targeted Cancer Drug Delivery with Enhanced Water Solubility was carried out. The main objective was to investigate how the HA-curcumin conjugate act as targeted drug delivery & with enhances water solubility. The software, Discovery Studio 2.5 generates a three-dimensional simulation of the conjugated drug. As a result the conjugation of curcumin with hyaluronic acid enhances its water solubility and stability, thus increasing bio-availability.

Item Type: Final Year Project
Subject: T Technology > TP Chemical technology
Divisions: ?? sch_che ??
Depositing User: Users 5 not found.
Date Deposited: 11 Jan 2012 12:23
Last Modified: 19 Jan 2017 15:45
URI: http://utpedia.utp.edu.my/id/eprint/493

Actions (login required)

View Item View Item