Thermodynamic Modeling for Liquid-Liquid Extraction of PEG-MgS04 system in MATLAB

This project focuses on the application of protein extraction in aqueous salt system. The
objective is to simulate a system which contains polymer and salt which will
subsequently be used to extract protein. This system is called as Aqueous Two-Phase
Extraction System (ATPES). ATPES is a liquid-liquid extraction system where the
extraction takes place when it reaches liquid-liquid equilibrium (LLE). This system
consists of water, polymer and salt. Both polymer and aqueous is allowed to attain
equilibrium where it forms two clear phase. The formation of two phase depends on
parameters such as pH value of system, temperature and concentration level. The model
used in this thermodynamic approach is Flory-Huggins model [1,2]. Flory-Huggins
model is a mathematical model of the thermodynamics of polymer solutions which
takes account of the great dissimilarity in molecular sizes in adapting the usual
expression for the entropy of mixing [1,2]. This project is a simulation-based project
using MATLAB. This software enables the author to find possible combination of
ATPES and to optimize protein recovery. First of all, the author needs to learn and
master using MATLAB software. Then some literature reviews need to be performed to
select the right ATPES. At the end of the project the results of this project will be
compared with experimental result which will be obtained through literature review.